Study of free amino acids in stratum corneum and plasma in patients with dermatophytosis and normal subjects

Background: Dermatophytes are a group of fungi that cause infections in keratinized human and animal tissues. Physical and chemical agents can be effective in reveals of dermatophyte pathogenesis in human which some people are sensitive and some other are resistance to it. Amino acid changes may be a risk factor for infection with dermatophytes in mammals. Methods: Amino acids in plasma and stratum corneum analyzed by HPLC method and the identification of dermatophytosis was based on direct examination and culture. The results of research statistically were analyzed by software and comparison of mean by using the t- test. Results: Achieved results between case and control in sole area have shown that cases were significantly increased in: Aspartate - Tyrosine –Tryptophane - Phenylalanine and were significantly decreased in: Citrulline– Ornithine similarly, in male and female. The results have shown that people with dermatophytosis in two site near skin lesion and sole area distribution in associated were significantly increased in: Glutamates - Asparagine - Histidine - Glutamine - Arginine - Citrulline - Threonine - Methionine - Leucine – Ornithine and were significantly decreased only in: Glycine . In plasma: Aspartate - Glutamates - Asparagine - Arginine - Threonine - Alanine - Tyrosine - Valine - Phenylalanine - Isoleucine – Leucine have statistical differences with significant p value (p? 0.05) between two groups ,case and control similarly, in male and female.