17Nov 2020


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Molecular hydrogen (H2) has demonstrated therapeutic properties across numerous models. To date, the mechanism underlying the beneficial responses to H2 exposure remains elusive. The initial hypothesis that molecular hydrogen acts as a direct, selective antioxidant in vivo does not reconcile models where H2 has shown to increase oxidative stress, nor does it explain numerous other physiological changes that have been observed throughout the literature. Some researchers have proposed that H2 acts as a hormetic stress. This hypothesis does not reconcile H2 being non-toxic in nature, even at high doses. Hormetic stressors have contributed to evolutionary adaptations, with the absence of these stressors causing cellular dysfunction. H2 has played an intimate role in the evolution of our planet’s atmosphere, the evolution of mitochondria and of life on the planet. Endogenously produced H2 volumes vary dramatically between individuals and are expected to have varied through human evolution. Our cells have evolved to tolerate erratic and intermittent exposure to H2. Intermittent exogenous H2 exposure yields results similar to various hormetic stressors. Continued research elucidating how H2 acts as an adaptive stressor, both through endogenous levels and exogenous supplementation, are highly warranted.

[Alex T. Tarnava (2020); EVOLUTION, ADAPTIVE STRESSORS AND MOLECULAR HYDROGEN Int. J. of Adv. Res. 8 (Nov). 216-219] (ISSN 2320-5407). www.journalijar.com

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Article DOI: 10.21474/IJAR01/11998      
DOI URL: http://dx.doi.org/10.21474/IJAR01/11998