The expression of cytokines and inflammatory bio-markers of Uterus muscles of patients with infectious and Non-infectious vaginitis
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The present study aimed to utilize the established immunohistochemical techniques to detect the presence of inflammatory cell infiltrate of cytotoxic T cells, macrophages, perforin, T helper 1 cells, T helper 2 cells and T regulatory cells and T helper 17 in uterus biopsies of patients with infectious and non-infectious vaginitis . CD8 and perforin positive cells were present in the Uterus section from patients with vaginitis in all patients 9/9 (100%) in whom 4/9 (44%) had a mean score of > +3 and 5/9 (56%) had a mean score of >+2 for both CD8 & Perforin . However the patients control (non-infectious vaginitis ) showed also CD8 and perforin positive cells but at lesser extent in whom 4/6 ( 67 %) had a mean score of >+2 and 2/6 (33.%) had a mean score of >+1 for CD8 while 5/6 (83 %) had a mean score of >+1, 1/6 (17 %) had a mean score of >+3 for perforin. While the bio-markers (CD68 , Foxp3 , Gata3 , Tbet , Th17 ) when non-significant in both infectious and Non-infectious vaginitis.
[Adnan H. Alhamadani, Omar M.Altaee, Ghada B. Alomashi, Munther J. Hussain (2015); The expression of cytokines and inflammatory bio-markers of Uterus muscles of patients with infectious and Non-infectious vaginitis Int. J. of Adv. Res. 3 (Jan). 0] (ISSN 2320-5407). www.journalijar.com
