Vol. 8 (12) pp. 538-542 DOI: 10.21474/IJAR01/12180

LYCOPENE EFFICACY TOWARDS STREPTOZOTOCIN INDUCE COGNITIVE DYSFUNCTION: A PRELIMINARY POSSIBLE FUTURE ALTERNATIVE FOR NEUROLOGICAL AILMENTS

  • Department of Clinical Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
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Abstract

Lycopene, a red-colored carotenoid,established for its antioxidant potentials towards cognitive dysfunction, a predictor of neurological maladies. Plentiful research in arena emphasizing towards formulation advancement and dose adjustment, incliningto impart an edge for lycopene biopotentials, but still leaving a lag. Current preliminary research emphasizes on therapeutic potentials of lycopene over cognitive dysfunction at certain doses established via behavioral models.Lycopene 100mg/kg dose depicted a significant immobility time curtail to 53.33±4.356secs in despair Test (DT), 25.67±2.028 crossing in Light and dark (LD) simulation, and 22.67±1.116 rotations in manual rota-wheels(RW) designrespectively,in contrast to STZ control 83.50±4.766 sec (DT), 14.67±1.764 (RD)and 9.333±1.606(RW) respectively.Lycopene 100 mg/kg dose depicted positive and impressive results against cognitive dysfunction. Prospectively,Lycopene could be utilized as an alternative supplement for neurological diseases.

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How to Cite This Article

Mohammad Yusuf (2020); LYCOPENE EFFICACY TOWARDS STREPTOZOTOCIN INDUCE COGNITIVE DYSFUNCTION: A PRELIMINARY POSSIBLE FUTURE ALTERNATIVE FOR NEUROLOGICAL AILMENTS, Int. J. of Adv. Res., 8 (12), 538-542, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/12180

Corresponding Author

Mohammad Yusuf
Department of Clinical Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.