COMPARATIVE EVALUATION OF EFFICACY OF TOPICAL SALICYLIC ACID OINTMENT AND 5-FLUOROURACIL CREAM IN WARTS PATIENTS

Context: Warts are one of the common diseases in India. There are various modalities used for the treatment of warts. Very few studies have been done which compare the efficacy of topical salicylic acid and 5-Fluorouracil cream in warts patients.

Aim: To compare the efficacy of topical salicylic acid ointment and 5% 5-fluorouracil cream in warts patients.

Settings and Design: Completely randomized design.

Methods and Material: Total 300 clinically diagnosed patients of warts which were divided into three groups (each contains 100 patients) depending on the treatment modalities which includes modality I treated with 16% salicylic acid, modality II treated with 5% 5-fluorouracil and modality III treated with the combination of 16% salicylic acid and 5% 5-fluorouracil. The evaluation of therapy was done by estimating the reduction in wart volume, complete regression of lesion, absence of recurrence of treated lesion after 3 months follow up.

Statistical analysis used: Significant conclusion was drawn after applying the one way Anova test of significance.

Results and conclusion: In Modality III, 99.95 % clearance was seen in warts volume at 12 weeks of treatment followed by Modality I (99.67% clearance in warts volume) and Modality II (99.31% clearance in warts volume) which were statistically significant at p value <0.01 level. Combination of 5-Fluorouracil and 16% salicylic acid is best for the treatment of warts with maximum recovery from warts with minimum adverse effect.