ROLE OF CIRCULAR RNAS IN TUMORIGENESIS AND THEIR POSSIBLE APPLICATIONS IN CANCER DIAGNOSIS AND TREATMENT
- Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University,Badr,Cairo-Suez Road 11829, Cairo, Egypt.
- Department of Tropical Medicine, Faculty of Medicine, Portsaid University, Egypt.
- Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, 11795, Ain Helwan, Cairo, Egypt.
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Circular RNAs (circRNAs) play critical roles in the development and progression of diseases, especially in cancer. Thus, expanding our understanding of circRNAs will enrich knowledge of cancer and give new opportunities for cancer therapy. In this review, we discuss the genesis of circular RNAs, their types and epigenetic aspects in tumorigenesis of abnormal cellular proliferation. The possible applications of individual circRNAs as biological markers in laboratory diagnosis of cancer received considerable attention recently.
[M. Samy Awad, Waleed Elagawy, H.A. Al-Sawaf, Heba Taha and Fathia Zaky El Sharkawi (2021); ROLE OF CIRCULAR RNAS IN TUMORIGENESIS AND THEIR POSSIBLE APPLICATIONS IN CANCER DIAGNOSIS AND TREATMENT Int. J. of Adv. Res. 9 (Feb). 571-577] (ISSN 2320-5407). www.journalijar.com
Lecturer of biochemistry and molecular biology, Faculty of Pharmacy, Helwan University
Egypt
