ROLE OF FUNCTIONALIZED GUAR GUM IN SOLID DISPERSION OF NON-STEOIDAL ANTI-INFlAMMATORY DRUG

The current investigation was developed to study the role of functionalized guar gum as carrier in solid dispersion of iboprofen. The solid dispersion technique using aminated guar gum would be an effective approach for increasing the solubility and increasing dissolution behaviour of ill fathomable medicament than the native guar gum. The results of FTIR and DSC studies confirmed that there is no chemical interaction or no incompatability between the drug and excipients. The invitro dissolution study was performed for the the prepared formulations. Based on the results SD3 was shown highest drug release 99.41% within 24hrs. Stabiliy study was conducted as per ICH guidelines and the falloutsrevealed that there is no physical or chemical change.it may be concluded that solubility of ibuprofen can br improved by using functionalized guar gum in the solid dispersion, which provides a wide scope for the therapeutic efficiency.