SERUM RESISTIN LEVELS AND CARDIOVASCULAR RISK FACTORS IN CHRONIC RENAL FAILURE RAT MODEL

Background: Chronic kidney disease is associated with markedly increased risk for cardiovascular events and mortality. Previous studies stated the possibility that resistin may relate to different cardiovascular dysfunction in different conditions. Aim: to investigate the relationship between serum resistin levels and cardiovascular risk factors in chronic renal failure (CRF) rat model. Material and methods:40 healthy male albino rats weighing 150-200 gm were used and divided into two groups: control group (15 rats) and CRF-induced group (25 rats) where CRF was induced by injection of folic acid subcutaneously (300 mg in 5 ml/kg once a week) for 3 weeks. Results:in CRF-induced group were significantly higherserum levels of resistin, urea, creatinine, glucose, insulin, total cholesterol and CRP, proteinurea, with significant elevation of mean arterial blood pressure, calculated HOMA-IR and atherogenic index than that of the control group.Serumresistin levels positively correlated with the previous parameters in the CRF-induced group. However, serum levels of HDL-cholesterol were significantly lower and negatively correlated with serum resistin levels in the CRF-induced group. In addition, in ECG, significant prolonged PR and QT intervals, lower amplitude of R-wave and higher amplitude of T-wave were detected but without correlation with serum levels of resistin in CRF group.There was significant positive correlation between atherogenic index and other parameters; serum levels of glucose, insulin, CRP, calculated HOMA-IR and mean arterial blood pressure. Conclusion:Resistin can be considered as uremic toxin of chronic renal failure, triggering mortality through aggravation of cardiovascular risk factors in CRF.