EFFECTS OF AQUEOUS EXTRACT OF DISSOTIS BRAZZEI COGN. ROOTS ON BIOLOGICAL PARAMETERS AND RISK FACTORS OF MYOCARDIAL INFARCTION IN NORMAL RATS

The present study aimed to evaluate the effects of the aqueous extract of the roots of Dissotis brazzeiCogn.(D. brazzei), on the parameters of myocardial infarction (MI) and its risk factors in normal rats. Among the cardiac pathologies cited by the population as heartache is the myocardial infarction. D.Brazzeiis a medicinal plant widely used in traditional Congolese medicine to treat heart diseases. In this study, rats were given the aqueous extract of the roots of D. brazzei(125, 250 and 500 mg/kg/day)for 7 days in, comparison with rats treated with distilled water (1 mL/100 g). The results obtained show that this extract has no significant effects on MI parameters (LDH, CK-MB, troponin I and CRP). Moreover, it causes variations at non-risk percentages of MI risk factors (blood pressure, body weight of rats, total cholesterol, HDL-C and Triglycerides). In conclusion, the aqueous extract of the roots of D. brazzei at the studied doses, does not modify the parameters of MI, nor does it promote the occurrence of the risk factors of MI. The evaluation of a cardioprotective study of this extract deserves to be carried out in rats.