ASTAXANTHIN AMELIORATES DIABETIC NEUROPATHY VIA MODULATING THE INFLAMMATORY CYTOKINES IN STZ INDUCED DIABETIC MICE

Background: Diabetic neuropathy (DN) is caused by hyperglycaemia which results in behavioral impairment, oxidative stress and inflammation.

Objective: The present study investigates the ameliorative effect of astaxanthin (AX) in brain tissue via modulating the inflammatory cytokines in diabetic neuropathic mice. This study was conducted by inducing diabetes in mice using STZ (40mg/kg i.p). To study ameliorative effect of AX on levels of TAS, TOS, OSI and expression of KLFs in brain tissue were analysed. Later, morphological impairments in neurons were studied in frontal cortex and levels of TNF-α, IL-1β, IL-6, inducible NO synthase (iNOS) and caspase-3 were analysed.

Results: AX administration attenuated STZ induced alternation in behavioural impairment, normalized the levels of TOS, OSI, TNF-α, IL-1β, IL-6, iNOS and caspase-3 level and significantly (p<0.001) increased the TAS.

Conclusions: This study revealed that AX optimised the levels of TOS, OSI, TAS and reducing the levels of TNF-α, IL-1β, IL-6, iNOS and caspase-3 in Diabetic mice. These suggest that AX could have a beneficial effect by ameliorates diabetic neuropathy via modulating the inflammatory cytokines.