19May 2022

A STUDY OF THE LEVELS OF SERUM MAGNESIUM AND SERUM ZINC IN PATIENTS OF SUBCLINICAL HYPOTHYROIDISM

  • Msc 3rd year student, Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital,Sharda University, Greater Noida, Uttar Pradesh, India.
  • Associate Professor, Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital,Sharda University, Greater Noida, Uttar Pradesh, India.
  • Assistant Professor, Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital,Sharda University, Greater Noida, Uttar Pradesh, India.
  • Professor, Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital,Sharda University, Greater Noida, Uttar Pradesh, India.
  • Professor, Department of Medicine, School of Medical Sciences and Research and Sharda Hospital,Sharda University, Greater Noida, Uttar Pradesh, India.
  • Professor, Department of Biochemistry, School of Medical Sciences and Research and Sharda Hospital,Sharda University, Greater Noida, Uttar Pradesh, India.
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Background: Subclinical Hypothyroidism (SCH), according to the endocrine web is defined as an elevationin in Thyroid Stimulating Hormone (TSH) level (4.6-10 m I U/L) with thyroid hormone levels in the normal range. Magnesium (Mg2+) is an essential macro-mineral in human body, which acts as a cofactor for more than 300 enzymes. Zinc (Zn+2) is required for proper functioning of 5-deiodinase & it is a cofactor for Thyrotropin -Releasing Hormone (TRH). Transcription factorsbind to thyroid hormones which are fundamental for modulation expression of gene, also contain Zn2+ bound to cysteine residues.

Aim and objectives: This study aim to estimate the levels of serum magnesium and zinc in patients of SCH.

Material and methods: The serum TSH, Total Triiodothyronine (T3)& Thyroxine (T4) levels were estimated by ELISA method to identify the cases of SCH. The concentration of serum magnesium was analyzed using semiautomated analyzerbyspectrophotometry. Serum zinc was analyzed by fully automated analyzer (Vitros 5600) in patients of SCH.

Results:In SCH, both T3, T4 were within the normal range and TSH in the range of 4.6-10 m I U/L, there was a statistically significant (p<0.001) decrease in serum zinc levels and not significantly decrease in serum magnesium levels in subclinical hypothyroidism patients.

[Thuraya Abdulsalam A.A.Al-Azazi, Shaliza Verma, Rajesh Kr Thakur, Manoj Kumar Nandkeoliar, V.P.S Punia and BC Kabi (2022); A STUDY OF THE LEVELS OF SERUM MAGNESIUM AND SERUM ZINC IN PATIENTS OF SUBCLINICAL HYPOTHYROIDISM Int. J. of Adv. Res. 10 (May). 297-302] (ISSN 2320-5407). www.journalijar.com

Dr. Manoj Kumar Nandkeoliar
professor, Dept of Biochemistry, SMSR, Sharda University
India

DOI:

Article DOI: 10.21474/IJAR01/14708      
DOI URL: http://dx.doi.org/10.21474/IJAR01/14708

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