EFFICIENT SYNTHESIS, ANTI-INFLAMMATORY AND ANTIBACTERIAL PROPERTIES OF 9- ARYL-6-(3-METHYLPHENYL)[1,2,4]TRIAZOLO[4,3-A]QUINOLINES
- Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana State-506001.
Abstract
A simple and highly efficiently method for the synthesis of 9-aryl-6- (3- methylphenyl)[1,2,4]triazolo [4,3-a]quinolines 8 by the oxidation of the corresponding aryl aldehyde 1-[3-(3-methylphenyl)quinolin-2- yl]hydrazones 7 using iodobenzene diacetate [PhI(OAc)2] in the solid state at RT under grinding conditions is described. The yields are very good and purity is high. The structures of compounds 3-8 were confirmed by their spectroscopic (IR, 1H NMR and MS) and analytical data. The compounds 8 have been tested for their antibacterial and anti- inflammatory activities.
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How to Cite This Article
Adaboina Srilekha, Kavati Shireesha, Shaganti Venkatesh and Kumara Swamy J. (2022); EFFICIENT SYNTHESIS, ANTI-INFLAMMATORY AND ANTIBACTERIAL PROPERTIES OF 9- ARYL-6-(3-METHYLPHENYL)[1,2,4]TRIAZOLO[4,3-A]QUINOLINES, International Journal of Advanced Research (IJAR), 10 (07), 316-323, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/15036
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