DESIGN AND CHARACTERIZATION OF FAST DISSOLVING TABLETS OF VALSARTAN USING SYNTHETIC AND NATURAL SUPERDISINTEGRANTS

The present study has a design the formulation of the valsartan fast dissolving tablets and evaluate which was prepared by using synthetic and natural superdisintegrants. Fast dissolving drug delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the fastest, safest,convenient and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets. Valsartan fast dissolving tablet formulations prepared by the direct compression method by using crosspovidone synthetic and gum karaya natural superdisintegrant .Formulations were evaluated for precompressional and postcompressional parameters like uniformity of weight, thickness, hardness, friability, drug content, wetting time, water absorption ratio, in vitro dispersion time, in vitro disintegration time and in vitro dissolution study.Results revealed that among the 6 formulations, the formulation S3 containing 7.5% of crospovidone and formulation N 3 containing 7.5% of Gum karaya was found to be promising formulation. S3 shown disintegration time of 9.22 seconds and the drug release was up to 96.78% in 30 minutes and N3 shown disintegration time of 16.34 seconds and the drug release was up to 75.60% in 30 minutes.