Vol. 10 (10) pp. 1087-1095 DOI: 10.21474/IJAR01/15584

STUDY OF SPECTRUM OF HEMOGLOBINOPATHIES IN ADULT AGE GROUP DIAGNOSED ON HIGH PERFORMANCE LIQUID CHROMATOGRAPHY IN TERTIARY CARE HOSPITAL

, , , and
  • Junior Resident 3, Department of Pathology, Dr PDMMC Amravati.
  • Professor, Department of Pathology, Dr PDMMC Amravati.
  • Head of Department and Professor, Department of Pathology, Dr PDMMC Amravati.
  • Associate Professor, Department of Pathology, Dr PDMMC Amravati.
  • Assistant Professor, Department of Pediatric. GMC Yavatmal.
14 Downloads 82 Views
Crossref

Download Full Paper (PDF)

Abstract

Background: Inherited abnormalities of hemoglobin synthesis (hemoglobinopathies) include a myriad of disorders ranging from thalassemia syndromes to structurally abnormal hemoglobin variants.

Aims and Objectives: To study spectrum of hemoglobinopathies in adult age group diagnosed on HPLC in tertiary care hospital.

Materials and Methods: The present study carried out in the deparment of pathology , DR PDMMC AMRAVATI over a period of 18 months from january 2021 to june 2022. A total of 800 cases were included in the present study. The age group of patients ranged from 19 years and above. HPLC , complete blood count, and peripheral smear examination were done in all the cases.

Results and Discussion: In the present study total 800 patients were included out of which 134 cases displayed abnormal hemoglobin fractions on HPLC. It was seen that majority of the patients in study were in the 19yrs to 30yrs. The most common hemoglobinopathy observed in the present study was sickle cell trait (51.50 %) followed by Beta Thalassemia trait (26.12 %) and Sickle cell disease (16.42 %).HbDpunjab trait was observed in 3.74 % cases. Sickle cell Disease + Beta thalassemia trait ,HbE trait, HbE homozygous were observed in 0.74% cases each.

Conclusion: Detection of Î²-thalassemia carriers and other structural variants will provide a preliminary insight to the prevalence of hemoglobinopathies in hospital based patients.Awareness can be created in an effort to prevent the birth of affected children.The present study is intended to contribute to the available data as the identification of these disorders is important epidemiologically and aids in  prevention of more serious hemoglobin disorders.

Keywords

How to Cite This Article

Supriya Patil, J.P. Laddha, R.R. Soni, Ashish Tayde and Ashish Patil (2022); STUDY OF SPECTRUM OF HEMOGLOBINOPATHIES IN ADULT AGE GROUP DIAGNOSED ON HIGH PERFORMANCE LIQUID CHROMATOGRAPHY IN TERTIARY CARE HOSPITAL, International Journal of Advanced Research (IJAR), 10 (10), 1087-1095, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/15584

Corresponding Author

Dr Supriya Devidas Patil
Junior Resident 3 in department of pathology , Dr PDMMC Amravati
India

Article Analytics

Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.