16May 2023

BIOPSY PROVEN ACUTE INTERSTITIA NEPHRITIS SECONDARY TO NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ABUSE IN A SIXTY TWO YEAR OLD MAN

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Acute interstitial nephritis (AIN) can be caused by non-steroidal anti-inflammatory drugs (NSAIDs) particularly in prolonged therapy and large doses. We present the management and reviewed the literature. Sixty-two year old man with, vomiting and hiccups of one week after seven weeks of daily Diclofenac sodium100mg and Meloxicam 15 mg, for body pains.

Results: He had asterixis. Laboratories showed pyuria, haematuria, anemia (28%), creatinine (714 µmol/L) and potassium (6.9 mmol/L). Histology showed acute interstitial nephritis. He had cardio-protective-treatment and haemodialysis, with kidney function restoration.

Conclusion: NSAIDs should be taken in low, single doses and, for short period to avoid AIN. Haemodialysis is beneficial in restoring kidney function. 


[Uduagbamen P.K, Shitu A.O, Ano-Edward GH, Idris S.O, Kasali O.E and Dairo I.O (2023); BIOPSY PROVEN ACUTE INTERSTITIA NEPHRITIS SECONDARY TO NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ABUSE IN A SIXTY TWO YEAR OLD MAN Int. J. of Adv. Res. 11 (May). 10-14] (ISSN 2320-5407). www.journalijar.com


Dr Peter K. Uduagbamen
Bowen University Teaching Hospital, Ogbomosho, Nigeria
Nigeria

DOI:


Article DOI: 10.21474/IJAR01/16842      
DOI URL: http://dx.doi.org/10.21474/IJAR01/16842