28Apr 2023

ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF STAPHYLOCOCCUS AUREUS ISOLATED FROM VARIOUS CLINICAL SAMPLES IN A TERTIARY CARE HOSPITAL

  • DepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad431003(Maharashtra)India.
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Background: Staphylococcusaureusisanosocomialpathogen,causinghighmorbidityandmortality.TheprevalenceofMRSAinfectionandthesusceptibilitypatternofStaphylococcusaureusvarieswiththeregion. WiththisbackgroundpresentstudywasundertakentodeterminetheprevalenceofstaphylococcusaureusandMethicillin-ResistantStaphylococcusaureus(MRSA)isolatesfromvariousclinicalsamplesandtheirantimicrobialsusceptibilitypatterninatertiarycarehospital.

MaterialsandMethods: Inthisretrospectivestudy,atotalof240isolatesofStaphylococcusaureuswascollectedfromaclinicalspecimen,betweenJune2021toMay2022intheDepartmentofMicrobiology,MGMMedicalCollegeandHospital,Aurangabad.StaphylococcusaureuswasidentifiedandtheirantibioticsusceptibilitytestingwasdeterminedbyusingVitek2compactsystemanddatawereanalyzed.

Result: Inourstudytotalof240StaphylococcusaureuswereisolatedandtheprevalenceofMSSAwas27.5%andtheprevalenceofMRSAwas72.5%fromvariousclinicalsamples. Outof240Staphylococcusaureusisolates,116(48.33%)wereresistanttoBenzylpenicillin,followedbyCiprofloxacin212(88.33%),Levofloxacin212(88.33%),Erythromycin154(64.17%),Clindamycin122(50.83%),Trimethoprim/Sulfamethoxazole120(50.00%),Gentamicin56(23.33%),Rifampicin15(6.25%)andTigecycline6(2.50%).

Conclusion: AhighprevalenceofMRSA(72.50%)wasobservedinourregion.ThemosteffectiveantibioticsforthetreatmentofMRSAwereLinezolid,Vancomycin,Teicoplanin,andTetracycline.TheseantibioticsshouldbekeptreservedforthetreatmentofMRSAinfection. Regularsurveillanceofhospital-associatedinfectionsisrequiredforassessingthetrendsintheantibioticresistanceofpathogensforstrengtheningthecontrolmeasurestopreventthespreadandreducetheemergenceofmultidrug-resistantMRSAinfections.

[Ajay A. Lokhande, Anupama S. Wyawahare, Mishra J.K. and Mulay M.V (2023); ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF STAPHYLOCOCCUS AUREUS ISOLATED FROM VARIOUS CLINICAL SAMPLES IN A TERTIARY CARE HOSPITAL Int. J. of Adv. Res. 11 (Apr). 261-268] (ISSN 2320-5407). www.journalijar.com

Dr. Wyawahare A.S.
Professor
India

DOI:

Article DOI: 10.21474/IJAR01/16649      
DOI URL: http://dx.doi.org/10.21474/IJAR01/16649

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