EXPLORING THE MOLECULAR MECHANISMS OF ANGIOGENESIS IN CANCER

Cancer is a complex disease characterized by the proliferation of faulty cells without apparent relation to the physiological organ. It is a multi-factorial, multi-staged, and multi-mechanistic process that involves interactions between environmental and host factors throughout its inception, progression, and manifestation. Inherited genetic predispositions contribute significantly to 5-10 percent of breast cancer and 5-13 percent of colon cancer cases. In industrialized nations, approximately 7 percent of cancer deaths are attributed to viral infections, 4 percent to occupational hazards, 2 percent to sunlight exposure, 2 percent to air, water, and soil pollution, and less than 1 percent to food components and industrial products. This review provides a comprehensive overview of the current research on the micro-metastatic state in solid tumors.