FORMULATION, DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLET OF ACECLOFENAC

In this study, sustained-release (SR) tablets of Aceclofenac were developed using acrypol 971Pas polymers. The tablets were prepared by mixing the active drug (Aceclofenac) with the polymer and other excipients, and then compressing the mixture into tablets using a tablet press.The release profile of the SR tablets was optimized by adjusting the ratios of the polymers and other excipients. The optimized formulation showed sustained release of the drug up to 16 hours, and the release kinetics followed first-order models. The tablets were stored under various conditions (e.g., at different temperatures and humidity levels) for a set period of time. The results showed that there were no significant changes in the drug content, physiochemical parameters. This suggests that the optimized SR tablets of Aceclofenac are stable and may be suitable for use as a sustained-release formulation of the drug.