Survey the Effect of Sodium Channel Voltage to Prevent the Production of Action Potential in order to Create a Local Anesthetic and its Simulation by MATLAB Software

In this study, survey the sodium channel effects on blocking the conduction of action potential and Simulation of sodium channel voltage reducing process have been explored. The simulation has been performed by using the Matlab software. First by using Hodgkin Huxley equations and simulation of them, action potential waveform is obtained which indicates that the nerve signals can be transmitted by it. The next step is when the pain is felt in the body and we will use anesthetics drugs to relieve pain. After using drugs, we know that the more, the effect of drugs on the body to create a local anesthetic increases, Sodium channel voltage is reduced and this will continue until the voltage reaches to zero and at this moment, the sodium channel is closed. Thus, sodium ions can not pass through the sodium channel and the action potential will not be producted and propagated inside of the axon. As a result, the body doesn’t feel pain and in other word, local anesthesia occur and this is clear in the simulation