Synthesis and Characterization of New Ligands attached to NSAIDs Moiety

A series of new analogues of Naproxen contain imidazole ring were synthesized (compound 7a-d). a group of amine derivatives incorporated in the carboxylate group of a naproxen, to increase its bulkiness were designed to be synthesized and evaluated as anti-inflammatory agents with expected inhibitory selectivity toward COX-2 enzyme. The anti-inflammatory activity of the tested analogues has been evaluated in comparison with propylene glycol 50%v/v (control group) and naproxen. The synthesis of the designed compounds has been successfully achieved. Purity and characterization of the synthesized compounds were confirmed by determination of physical properties (melting points and Rf values), FT-IR and 1H-NMR spectroscopies.