Anti-inflammatory effect of aqueous extract of Emblica officinalis in animal models

Background: The importance of inflammatory diseases and side effects of conventional drugs necessitate the discovery of new anti-inflammatory agents from natural sources. In this study,the mechanism of action of anti-inflammatory action of the aqueous extract of Emblica officinalis was evaluated in animal models. Methods: Forty-eight male Wistar albino rats were divided into six groups and three groups were pretreated with indomethacin,celecoxib and chlorphineramine maleate. The two groups were pretreated with misoprostol and different doses of Emblica offinalis extract. The aqueous extract of Emblica officinalis was administeredbefore the injection of carrageenan. Paw edema was measured by a plethysmometer at 1st, 3rd and 5th hour and compared to standard drugs. Results: The aqueous extract of Emblica officinalis decreased the rat paw edema in a dose-dependent manner. The effect on inflammation of the highest dose of extract was comparable to indomethacin. Emblica officinalis extract at dose of 600mg/kg showed decrease in paw edema when combined with misoprostol. Conclusions: The aqueous extract of Emblica officinalis reduced the inflammation in a dose-dependent manner mediated by inhibiting the action of prostaglandins and is a good candidate for further studies of safety and efficacy. The clarification of active components of the plant is necessary.