Improved Determination of Pinaverium Bromide in Pharmaceutical Preparations and Human Urine Utilizing a Coated Wire Electrode
- Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
- Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
- Faculty of Industrial Education, Beni-Suef University, Beni-Suef, Egypt.
- Chemistry Department, Faculty of Science, Taif University, Taif, KSA.
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Our efforts to lower the detection limit for a pinaverium ion-selective electrode were presented. Coated graphite CGE and coated silver CSE electrodes for pinaverium ions based on pinaverium-tetraphenylborate (pina-TPB) and pinaverium-reineckate (pina-RT) as electroactive materials are described. The sensors show Nernstian slopes of 59.5±0.4 and 59.2±0.2 mV decade-1 with detection limits of 6.3×10-7 and 6.3×10-7 mol L-1 pinaverium bromide for CGE and CSE, respectively. Furthermore, the sensors showed invariable potentials in the pH range of 3-11 for CGE and CSE. The present electrodes exhibit clear discrimination of pinaverium bromide from several inorganic cations, sugars and amino acids. The sensors have been used for the determination of pinaverium bromide in human urine and pharmaceutical preparations via potentiometric titration, standard addition and the calibration curve methods. The results were acceptable with excellent accuracy and precision.
[M. M. Khalil, Y. M. Issa, S. I.M. Zayed, N. A. Mohamed (2015); Improved Determination of Pinaverium Bromide in Pharmaceutical Preparations and Human Urine Utilizing a Coated Wire Electrode Int. J. of Adv. Res. 3 (Jun). 638-652] (ISSN 2320-5407). www.journalijar.com
