31Jul 2015

Synthesis and Reactions of Some 3-pyrazolyl-thiophene Derivatives and Thienotriazolopyrimidine Derivatives with Potential Anti-tumor and Antimicrobial Activities

  • Department of Chemistry, Faculty of Science, Al-Azhar University(Girls), Nasr City, Cairo
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Two series of 4-naphthyl-2-amino-3-pyrazolylthiophene derivatives and thienotriazolopyrimidineswere prepared from 4-naphthyl-3-(carboethoxy/cyano)-2-aminothiophene. Moreover, compounds 18 and 20 were tested as potential anti-tumor activity against both of human breast cancer (MCF-7) and human colon cancer (HCT-116).Some of the newly synthesized compounds showed potent antimicrobial activity.

[N.A.Marzouk, N.M.Taha, E.A. Eslam, A. Ali and J.A. Micky (2015); Synthesis and Reactions of Some 3-pyrazolyl-thiophene Derivatives and Thienotriazolopyrimidine Derivatives with Potential Anti-tumor and Antimicrobial Activities Int. J. of Adv. Res. 3 (Jul). 244-255] (ISSN 2320-5407). www.journalijar.com

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