STUDY OF CORRELATION OF SMOKING IN CAUSATION,SEVERITY AND PROGNOSIS OF ACUTE PANCREATITIS

Acute pancreatitis (AP) is a common and potentially severe inflammatory condition of the pancreas. While gallstones and alcohol use are recognized risk factors, emerging evidence suggests that cigarette smoking may also play a significant role in its pathogenesis. This study explores the correlation between smoking and the development and progression of acute pancreatitis. Findings indicate that smoking is associated with an increased risk and greater severity of AP, independent of other contributing factors. These insights underscore the need to consider smoking as a modifiable risk factor in both the prevention and clinical management of acute pancreatitis.

Objective: This study is done to: 1.calculate the APACHE II score for acute pancreatitis for disease severity at the time of admissionand to calculate ransons score for the prognosis of the patient 2.determine type of smoker(former,current,non smoker) a)former smoker-person who has quit smoking 6 or more months back b)current smoker-person who is smoking in the present c)non smoker- person who has not smoked ever in his/her life 3.find out the relationship, if any, between the type of smoking and the severity of acute pancreatitis

Methods: This hospital based retrospective open case study includes patients admitted to a tertiary care hospital at Navi Mumbai from September 2024 to April 2025. Due clearance was taken for the study from the ethics committee of the medical college. The patients admitted from OPD or emergency room were explained about their involvement in the study and due consent was taken. The on-call surgery team did the initial assessment and resuscitation. Patients were then shifted to wards or surgical ICU based on their condition on admission. A complete blood profile and radiological assessments were done. Patients progress was monitored from the time of admission till discharge. The APACHE II scoring system was used to determine the severity of acute pancreatitis along with CT findings. (Balthazar CT severity score). Ransons score was used at the time of admission and then 48 hours later to see the prognosis of the disease. A detailed questionnaire was made to determine the type of smoker(current/former/nonsmoker). A correlation was made to establish between the severity of acute pancreatitis and their smoking status.