PROGNOSTIC SIGNIFICANCE OFNEUTROPHIL LYMPHOCYTE RATIO AT ADMISSION IN ACUTE MYOCARDIAL INFARCTION

Introduction: Acute myocardial infarction (AMI) is the most common contributor ofmorbidity and mortality worldwide. Leukocytosis, predominantly neutrophilia has previously been described following AMI. Neutrophilsexacerbate vascular plugging, secrete inflammatory mediators that aggravatemyocardial ischemia. The Neutrophil-to-Lymphocyte ratio (NLR) stands out as the most reliable hematological marker for forecasting mortality or myocardial infarction in individuals at elevated risk for coronary artery disease and also serves as a strong indicator of long-term mortality among patients admitted with ST-segment elevation myocardial infarction (STEMI) as well as those receiving percutaneous coronary intervention (PCI)1,2 Toascertaintheprognostic significance of Neutrophil Lymphocyte Ratio (NLR)on the severity, morbidity, and mortality in patients with acute myocardial infarction during hospitalization, the current study is being conducted.

Materials and Methods:Study population: All patients who are diagnosed with acute myocardial infarction and are admitted to departments of General Medicine and cardiology in Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundationduring the study period. Blood samples were collected within 24 hours of hospital admission, and investigations were performed to assess total leukocyte count, differential count and neutrophil/lymphocyte ratio. Outcomes were subsequently assessed, and the results obtained were subjected to statistical analysis.