COGNITIVE-ENHANCING EFFECT OF ETHYL ACETATE FRACTION OF ERYTHROPHLEUMIVORENSE STEMS BARK AGAINST KETAMINE-INDUCED MEMORY IMPAIRMENT IN MICE
Olayemi K. Wakeel
, Okoduwa J. Omoabhiena
, Damola O. Komolafe
, Akeem A. Ayankunle
, Timotheu O. Kolawole
, Oluwasewa O. Ademola
and SamuelA. Ademola
- Department of Pharmacology and Therapeutic, Faculty of Basic Clinical Sciences, College of Health Sciences, LadokeAkintola University of Technology Ogbomoso, Nigeria.
- Department of Veterans Affairs, Harvard Medical School Post Graduate: Safety, Quality, Informatics and Leadership, Veterans Healthcare System Phoenix Arizona, USA.
- Department of Mental Health Nursing, Faculty of Nursing Sciences, Osun State University Osogbo, Osun State, Nigeria.
- Department of Pharmacology and Therapeutic, Faculty of Basic Clinical Sciences, College of Health Sciences, Osun State University Osogbo, Osun State, Nigeria.
- Department of Chemical Pathology, Faculty of Basic Clinical Sciences, Reedemer University, Ede, Osun State, Nigeria.
- Department of Histopathology, Faculty of Basic Clinical Sciences, Osun State University, Osogbo, Nigeria.
- Abstract
- Keywords
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- Corresponding Author
Background:Conventional treatments for managing Alzheimers disease (AD) and related cognitive deficits are not said to be curative; they relieve symptoms but can result in adverse side effects. Additionally, the use of herbal therapies to manage cognitive illnesses has increased significantly. Erythrophylum ivorense is commonly used in herbal medicine to manage neurological disorders. The present study evaluated the cognitive-enhancing potential of the ethyl acetate fraction of Erythrophleum ivorense (EAFEI) against ketamine-induced memory impairment in mice.
Materials and Methods: Ketamine (15 mg/kg) was administered to Induce memory impairment.Donepezil (1 mg/kg) served as thestandard reference compound.An ethyl acetate fraction of Erythrophleumivorense (20, 40, 80 mg/kg) was evaluated for its cognitive enhancing effects, as by step through latency in a passive avoidance test.Additionally, the anti acetylcholinesterase (anti AChE) activity and antioxidant potential of the extract were assessed using brain tissues from the test animals transmission.
[Olayemi K. Wakeel, Okoduwa J. Omoabhiena, Damola O. Komolafe, Akeem A. Ayankunle, Timotheu O. Kolawole, Oluwasewa O. Ademola and SamuelA. Ademola (2025); COGNITIVE-ENHANCING EFFECT OF ETHYL ACETATE FRACTION OF ERYTHROPHLEUMIVORENSE STEMS BARK AGAINST KETAMINE-INDUCED MEMORY IMPAIRMENT IN MICE Int. J. of Adv. Res. (Jul). 722-729] (ISSN 2320-5407). www.journalijar.com
