CARCINOSARCOMA OF THE UTERINE CERVIX: A CASE REPORT WITH IMMUNOHISTOCHEMICAL ANALYSIS

  • Senior Consultant and HOD of Histopathology and Cytology, HCG Cancer Center, Ahmedabad.
  • Fellow in Oncopathology, HCG Cancer Center, Ahmedabad.
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Carcinosarcoma of uterine cervix is a rare neoplasm. This report describes the histopathological and immunohistochemical profiles of a malignant cervical tumor with a mixed morphology of mesonephric carcinosarcoma and HPV dependent squamous cell carcinoma. A 51 year old female presented with the complain of bleeding per vagina since 2 weeks. MRI revealed a 36 x 50 x 45mm lesion involving cervix, lower uterine segment and vaginal fornices. The final histomorphology revealed a poorly differentiated tumor with mixed features of squamous cell carcinoma and mesonephric carcinosarcoma.Immunohistochemical analysis revealed expression of p40, p63, p16 and AR in squamous component and expression of GATA3,CD10 and Calretinin in mesonephric component. P16 positivity in squamous cell component indicated HPV associated carcinoma.The immunological findings support the metaplastic theory that carcinosarcoma may stem from the carcinomatous elements and then differentiate into sarcoma components.The coexistence of carcinosarcoma and cervical squamous cell carcinoma in our patient support this theory. Immunohistochemistry plays an important role for diagnosis of such unusual mixed type of tumors.

[Shubhada Apoorva Kanhere and Bhumi Patel (2025); CARCINOSARCOMA OF THE UTERINE CERVIX: A CASE REPORT WITH IMMUNOHISTOCHEMICAL ANALYSIS Int. J. of Adv. Res. (Jul). 1176-1178] (ISSN 2320-5407). www.journalijar.com

Dr. Bhumi Patel

India

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