Invitro Studies of Different Brands of Cephalexin Monohydrate Capsules (500mg) Available In Local Market (Pakistan)

Drugs and health care structures are no more reliable for community because of substandard and poor quality medicines, which are dangerous for human health and life, so it is important to check the approved medicines to assess their efficacy and safety for the whole population. The present study is to investigate the invitro comparison of 5 different brands of cephalexin monohydrate capsules available in Pakistan.The invitro parameters include dissolution rate, weight uniformity, disintegration time, and HPLC assay of cephalexin.This study reveals that weight of all brand of capsules lies within the pharmacopeia limit, that is +-7.5%. dissolution process was carried out according to USP method and potencies of all brands were within the specified range, that is not less than 80% of the labeled amount is dissolved in 30 minutes (USP 2007), and all capsules disintegrates within 5 minutes that lies in the USP range, according to USP maximum time for capsule disintegration is 15 minutes. Overall purpose of the study is to provide safe interchangeable drug to the public.