EVALUATION OF SUB-TENON MITOMYCIN-C TRABECULECTOMY WITH AMNIOTIC MEMBRANE TRANSPLANTATION IN GLAUCOMA: A SINGLE ARM PROSPECTIVE STUDY

Background: Long term success of trabeculectomy is largely dependent on modulation of postoperative wound healing. Conventional sponge-applied mitomycin-C (MMC), although effective, is associated with variability in dosing and bleb-related complications. Sub-tenon MMC injection and amniotic membrane transplantation (AMT) have emerged as adjuncts aimed at improving bleb quality and surgical safety. Aim: To evaluate the efficacy and safety of trabeculectomy augmented with sub-tenon MMC and amniotic membrane transplantation in patients with glaucoma. Materials and Methods: This prospective interventional study included 21 patients with medically uncontrolled primary open-angle or primary angle-closure glaucoma.All patients underwent trabeculectomy with standardized sub-tenon MMC injection followed by placement of cryopreserved amniotic membrane over the scleral flap. Pre- and postoperative intraocular pressure (IOP), anti-glaucoma medication requirement, bleb morphology, complications, and surgical outcomes were assessed during follow-up.