ANTIBACTERIAL ACTIVITY OF AQUEOUS AND ETHANOLIC ROOT EXTRACTS OF PERICOPSIS LAXIFLORA AGAINST MULTIDRUG-RESISTANT UROPATHOGENIC BACTERIA ISOLATED FROM PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

Urinary tract infections are a fairly common complication in patients with benign prostatic hyperplasia (BPH). Indeed, urinary tract obstruction and urinary retention facilitate bacterial proliferation in these patients. This study aimed to evaluate the antibacterial activity of aqueous and ethanolic extracts of Pericopsislaxiflora roots against multidrug-resistant bacteria isolated from the urine of patients with BPH. Antibacterial activity was assessed using the agar diffusion method (zone of inhibition) combined with double dilutions in liquid media (MIC, MBC) against four uropathogenic bacterial strains: Klebsiella pneumoniae, Proteus mirabilis, Proteus spp., and Escherichia coli.The inhibition zone diameters obtained with the ethanolic extract ranged from 11.2 mm to 16.1 mm, while those of the aqueous extract ranged from 8.1 to 10.5 mm. The minimum bacterial counts (MBCs) of the ethanolic extract were 12.50 mg/mL (P. mirabilis, Proteus spp.) and 50 mg/mL (K. pneumoniae, E. coli), respectively. The MBCs of the aqueous extract ranged from 50 mg/mL to 100 mg/mL. Both extracts exhibited bactericidal activity against all strains studied. These results suggest that P. laxiflora could be a potential source of new antimicrobial molecules for the treatment of urinary tract infections, which are quite common in patients with benign prostatic hyperplasia.