THE ROLE OF CONCURRENT RADIO-CHEMOTHERAPY IN THE MANAGEMENT OF LOCALLY ADVANCED INOPERATEABLE SQUAMOUS CELL CARCINOMAS OF THE LARYNX

To investigate the role of concomitantchemo radiotherapy in the management of inoperable squamous cell carcinomas of the larynx, we conducted a retrospective study of 50 cases collected over a 10-year period from January 2012 to December 2021. The study considered various clinical, radiological, endoscopic, therapeutic, and prognostic aspects of this condition. The mean age of the patients was 62.12 years, with a male-to-female ratio of 1.567. The diagnostic approach was consistent, based on clinical, endoscopic, radiological, and histological data. Therapeutic management involved induction chemotherapy in 76% of patients, combined with local treatment using chemo radiotherapy. Laryngeal cancer is a common malignancy of the upper aero digestive tract, primarily affecting older men and associated with alcohol and tobacco use. It is often diagnosed at advanced stages. The diagnostic process relies on a multimodal approach: clinical, endoscopic, radiological,and histological. Total laryngectomy, although curative, causes significant functional and psychological impacts. Larynx-preserving strategies have emerged as key approaches, offering good oncological outcomes but with notable acute and late toxicities. Hence the importance of holding a multidisciplinary consultation meeting.