Prevalence Of Metabolic Syndrome After Orthotopic Living-Donor Liver Transplantation

Liver transplantation (LT) is a life - saving procedure for patients with advanced liver diseases. Post-transplantation metabolic syndrome (PTMS), a consequence of LT, was associated with major vascular events; rapid progression of graft fibrosis and graft loss. The aim of this study was to assess the prevalence of metabolic syndrome (MS) following living-donor liver transplantation (LDLT) and the possible risk factors predisposing to it. Patients & Methods: A retrospective -prospective study was conducted on 85 Egyptian patients who underwent LDLT in the liver transplantation unit of the Military International Medical Center (IMC) - Cairo and completed one year of regular follow up. Results: Eighty five percent of our patients were males & mean age was 52 years. Pre-transplantation prevalence of MS, impaired fasting plasma glucose (FPG), DM, hypertension (HTN), Hypertriglyceridemia, Low serum High density lipoprotein (HDL) and Obesity was 14.1% , 12 % , 31 % , 11% , 2 % , 89 % and 22 % respectively. Post-transplantation prevalence of MS, impaired fasting plasma glucose (FPG), DM, hypertension (HTN), Hypertriglyceridemia, Low serum High density lipoprotein (HDL) and Obesity was 48% , 14 % , 77 % , 59% , 51% , 32 % and 35 % respectively. Conclusion: PTMS is an early and prevalent phenomenon after LDLT and its possible risk factors are pre-transplantation diabetes, pre- transplantation family history of diabetes and post - transplantation Obesity & Cyclosporine use.