Vol. 4 (07) pp. 1226-1235 DOI: 10.21474/IJAR01/1009

CYCLIC UREA ANALOGUES AS INHIBITORS OF JACK BEAN UREASE.

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  • Department of Chemistry, University of Delhi, New Delhi-110007, India.
  • Custom House Laboratory, Custom House, Vasco-Da-Gama, Goa, India
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Abstract

Based on the structural homology with urea, the substrate of urease, a variety of cyclic urea analogues viz. barbiturate, imidazolidinone and imidazolone derivatives were tested for their effect on jack bean urease in 50mM phosphate buffer, pH=7.0. These compounds were found to inhibit jack bean urease in a concentration dependent manner IC50 varies from 0.6 mM to 3.5mM with no further time dependent changes in the reaction velocities. Evaluation of the kinetic data from Lineweaver-Burk plots and Dixon plots revealed that the analyzed compounds act as reversibile competitive inhibitors of the plant enzyme.

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How to Cite This Article

Jitender M. Khurana, Vandana Sharma, Devanshi Magoo and Subhash Chandra. (2016); CYCLIC UREA ANALOGUES AS INHIBITORS OF JACK BEAN UREASE., Int. J. of Adv. Res., 4 (07), 1226-1235, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/1009

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SUBHASH CHANDRA

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