Immunohistochemical expression of pituitary Luteinizing hormone and Follicle stimulating hormone in male Rats treatment with thymoquinone.

To examine the effect of thymoquinone on the expression level of pituitary luteinizing hormone and follicle stimulating hormone in pubertal male rats , a total of 48 male rats aged 60 days were assigned to two equal groups. First group was drenched distilled water and served as control while second group was drenched with thymoquinone suspension (50 mg/kg) daily for six weeks. Two weeks internal , eight males were sacrificed and pituitaries were dissected for immunohistochemical examination . the results revealed higher expression of luteinizing hormone and follicle stimulating hormone in thymoquinone treated males with gradual increment as treatment periods progressed . it can be concluded that thymoquinone have potent role in elevation of pituitary hormone related to reproduction and fertility.