Correlation between Cyp19A1 protein with estrogen and testosterone in sera of Iraqi autistic children

Autism spectrum disorder is a spectrum of behavioral anomalies characterized by impairment in social interactions and communication deficits. A potential role for hormonal dysfunction has been suggested in autism. This study conducted to detect correlation between cyp19a1 protein and testosterone, estradiol hormone among Iraqi autistic children. The study includes: 50 child (36male and14 female) aged < 5 - 10 years with confirmed diagnosis of autism using standard assessment, age and gender matched 25 confirmed healthy children (non autistic) used as controls. Serum was isolated and used for measuring the levels testosterone, estradiol and cyp19a1 by using enzyme linked immunosorbent assay. In the current results indicate a significant decrease (P > 0.05) in levels of serum levels of cyp19a1 and estradiol for autism compared with the apperantly healthy control group, Whereas level of testosterone in the autistic patient's serum showed a significantly increased level (P < 0.05) compared with healthy control. In addition, present results showed positive correlation between cyp19a1 and estradiol with significant difference (P ? 0.05). While the correlation between cyp19A1 receptor and testosterone was negative with non-significant differences (P ?0.05). From this study concluded CYP19A1 reduction may be lead to reduced conversion of testosterone to estradiol resulting in elevated levels of testosterone as observed in ASD subjects.