Design and synthesis of some novel sulfonamide derivatives as potential antimicrobial agents

A series of novel of sulfonamide derivatives were synthesized from N-(4-(N-quinoxalin-2-ylsulfamoyl) phenyl) acetamide 1 and the structure of the newly compounds was con?rmed on the basis of elemental analysis and spectral data. All the compounds were screened in vitro for their antibacterial and antifungal activities. Especially, 2-[1-(4-(N-quinoxalin-2-ylsulfamoyl) phenyl amino) ethylidene] hydrazine carbothioamide, 4-(2-aminothiazol-4-ylamino)-N-(quinoxalin-2-yl) benzene sulfonamide, 3-( 4-hydroxy- 3-meth- oxy phenyl) -N-[ 4- (N-quinoxalin- 2yl sulfamoyl) phenyl] acrylamide, 4-[5- cyano-4-(4-hydroxy-3-methoxyphenyl)-6-oxo-1,6-dihydropyridin-2-ylamino ]-N-(quinoxalin-2-yl) benzene sulfonamide were found to be the most potent compounds against all the tested strains except for Candida albicans (RCMB 05036) and Pseudomonas aeruginoca (RCMB 010043).