Effects of omega-3 fatty acid in experimentally induced obesity in rats
- Department of Biochemistry, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt.
- Department of Biochemistry, Faculty of Veterinary medicine, Minia University, El Minia, Egypt.
- Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
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High-fat diet (HFD) administration lead to increased onset of obesity. Obesity, associated with metabolic abnormalities as glucose intolerance and hypercholesterolemia increased mortality rates. In obesity, adipose tissue expands to accommodate this increase in exogenous lipids and endogenous lipid synthesis leading to overall weight gain. An Omega-3 fatty acid used in this study as a treatment to modulate these metabolic disturbances. This study was designed to elucidate the effect of Omega-3 fatty acid on high fat diet induced obesity in albino Wister rats. Obesity induced by allowing rats to feed on the high fat diet for 20 weeks. Omega-3 fatty acid was used in doses of 0.8 mg/Kg body weight. Plasma glucose and total cholesterol were measured by enzymatic method. It can be concluded that administration of high fat diet caused obesity in rats via abnormal or extensive fat accumulation when energy intake exceed energy expenditure. Omega-3 fatty acid succeeded in ameliorating the deleterious effects of high fat diet induced obesity.
[Reem M. Hashem, Kamel M. A. Hassanin, Laila A. Rashed and Asmaa O. Ahmed (2015); Effects of omega-3 fatty acid in experimentally induced obesity in rats Int. J. of Adv. Res. 3 (Nov). 726-731] (ISSN 2320-5407). www.journalijar.com
