Antidiabetic activity of Anisomels indica Kuntze leaf flavonoid fraction in normal and alloxan induced diabetic mice

Diabetes mellitus is a major health problem in most of the countries. Purpose of the study was to evaluate the antidiabetic activity of leaf flavonoid fraction (LFF) of Anisomeles indica in normal and alloxan induced diabetic mice. Alloxan monohydrate 150 mg/kg body weight was used to induce diabetes mellitus. The LFF of A. indica at 500 mg and 1000 mg and glibenclamide at 7 mg/kg body weight administered individually to normal and alloxan induced diabetic mice significantly reduced the blood glucose. Also the administration of LFF significantly decreased serum total cholesterol, triglyceride and aspartate transaminase and alanine transaminase levels. Oral glucose tolerance test was performed by administration of A. indica LFF at 500 and 1000 mg/kg body weight and glibenclamide at 7 mg/kg body weight to different groups of animals. A. indica LFF and glibenclamide significantly lowered blood glucose levels at all time points that were sampled after oral glucose load. Results of the present study suggest that, A. indica LFF possess antidiabetic property and effective in lowering blood glucose level in diabetic mice.