HEPATOPROTECTIVE ROLE OF BASELLA RUBRA ON 1, 2-DIMETHYLHYDRAZINE INDUCED COLON CARCINOGENESIS IN RAT MODEL

The main objective of the study is to determine the hepatoprotective efficacy of Basella rubra against chemically induced colon carcinogenesis model. The study was performed in male Wistar rats allocated into six groups. First group considered to be normal control and second group as drug control receives Basella rubra aqueous extract (BRAE 250mg/kg b.w.) orally for 30 weeks, third group served as cancer control injected with only DMH (25mg/kg b.w.) for 15 consecutive weeks. Rats in group IV and VI were administered with BRAE along with DMH injections. Rats in group V were administered with BRAE after cessation of DMH injection. After 30 weeks of experimental period, all the organs were collected and the liver tissue from all groups of rats was subjected to lipid peroxidation (LPO) and histological studies. Protective effects of BRAE were observed by increased in consumption of food and body weights in BRAE administration groups. Increased levels of LPO were seen in only DMH injected rats; BRAE administration to DMH injected rats significantly decreased the levels of LPO in liver tissue. Histopathological findings revealed that high level of damage was seen in only DMH induced rats whereas administration of BRAE shows recovery in liver architecture and the improved results were observed in entire period administration of BRAE. From the above results, it can be concluded that Basella rubra possess the hepatoprotective effect against chemically induced colon carcinogenesis in rats. The effect was more pronounced in entire period administration of BRAE.