Histopathological effect on different rat tissues induced by the trihalomethane- chloroform administered in drinking water
- Departments of Biochemistry, Molecular Biology, Faculty of Science and Technology, El- Neelain University, SUDAN.
- Department of Biochemistry, Faculty of Marine Science, Red Sea University , SUDAN.
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The experiment was designed to investigate the histopathological changes in rat’s tissues due to the effect of the trihalomethane (THM) - chloroform when administered in drinking water. A group of male Wistar rat was exposed to trihalomethane-chloroform (TCM) at concentration 750 ppm in their drinking water and dose 16.17 mg/kg for a month. The growth rate and food intake were not affected by treatment, but TCM reduced significantly water consumption. This study demonstrate that, the THM-chloroform administered in the drinking water induced toxicity to the liver, hyperplasia in the urinary bladder and metaplasia in the small intestine of rats, but no effect on the kidney demonstrated in the current study.
[M. I. Abd El-Halim, Mohammed S. Y., O. F. Idris and M. K. Sabahelkhier (2015); Histopathological effect on different rat tissues induced by the trihalomethane- chloroform administered in drinking water Int. J. of Adv. Res. 3 (Nov). 1319- 1329] (ISSN 2320-5407). www.journalijar.com
