STUDY OF GLYCEMIC BIOMARKERS IN DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE

Background: Diabetic nephropathy is the most common aetiology of end stage kidney disease (ESKD). Strict glycemic control reduces the development and progression of diabetes-related complications, and there is evidence that improved metabolic control improves outcomes in diabetic subjects with chronic kidney disease (CKD). Materials and Methods: The present study has been conducted on 150 diagnosed & clinically established patients of Diabetes mellitus with nephropathy,who attended OPD and wards of Medicine and Department of Urology, J.L.N. Medical College and Associated group of Hospitals, Ajmer. These patients were compared with 150 Diabetic without nephropathy subjects. Anthropometric measurements and biochemical estimations were performed. Ethicalclearance was obtained before start of the study. Results: The Mean ± SD values of blood glucose ( Fasting & PP), serum creatinine, serum fructosamine, GHb and serum glycated albumin were observed statistically highly significant (p<0.0001) in CKD-3 subjects as compared with non CKD subjects.Conclusion: Prospective studies testing pre-specified diabetes control targets based on glycated albumin and continuous glucose measurement remain to be performed in order to determine whether morbidity and mortality would be reduced with intensive glycemic control using these measurements as reference target.