PATHOLOGIC CHANGES IN THE ADJACENT GASTRIC MUCOSA IN SURGICAL SPECIMENS REMOVED FOR GASTRIC CARCINOMA

This study was undertaken to determine the pathological changes in the gastric mucosa in gastrectomy specimens removed for gastric carcinoma at a tertiary care centre. Sixty four such gastrectomy specimens were received during a six year period between January 2009 and January 2015. There were 47 (73.43%) males and 17 (26.56%) females ranging in age from 31-60 years. The most frequent subtype was the intestinal type (84.32%) followed by the diffuse type (15.6%). Changes observed in the adjacent mucosa were atrophic gastritis (51 cases), intestinal metaplasia (49 cases), Helicobacter pylori infection (44 cases) and dysplasia (47 cases). There was a high percentage of associated chronic atrophic gastritis in intestinal type of carcinoma (88.18%) as compared to diffuse type (50%). Intestinal metaplasia was more common and distinct in intestinal type (83.33%) compared to diffuse type (40%). Helicobacter pylori was seen in 79.01% of intestinal type and 40% of diffuse type. Dysplasia was seen in both the intestinal (75.92%) and diffuse types (60%).