TO FIND ASSOCIATION BETWEEN QTc INTERVAL AND MICROALBUMINURIA IN TYPE-2 DIABETIC PATIENTS

Introduction - Diabetic nephropathy is a leading cause of diabetes related morbidity and mortality. Microalbuminuria is a strong predictor of glomerular injury and premature cardiovascular death in diabetic nephropathy. Diabetic cardiac autonomic neuropathy is a serious and common complication of diabetes. QTc prolongation is a predictor of cardiac autonomic neuropathy. Aim - The present study was done to find the association between QTc interval and microalbuminuria in type-2 diabetes mellitus. Material and method - 100 patients of Type-2 diabetes mellitus without nephropathy (group A-50 patients) and with nephropathy (group B-50 patients) were included in this study. All these patients were tested for microalbuminuria by nycocard U-albumin test and QTc interval prolongation in ECG. Study was statistically analysed by student-t test . Result - The mean microalbuminuria and QTc showed positive relationship in patient of type-2 diabetes mellitus with microalbuminuria. Conclusion - QTc interval serve as marker of increased cardiovascular mortality and morbidity in Type-2 diabetes mellitus patientswith and without nephropathy and its severity predicted from increasing QTc interval.