Clinicopathological Studies on the Chemotherapeutic Effect of Silymarin and Taurine on N-nitrosodiethylamine induced hepatic cell carcinoma in Rats

This new study was performed to investigate the chemotherapeutic effect of both silymarin and taurine alone or in combination on rats with N-nitrosodiethylamine (NDEA) induced hepatic cell carcinoma. Seventy five adult male albino rats were divided into five equal groups; the first was the negative control group(C). The second was the hepatic cell carcinoma group (HCC).The third was the hepatic cell carcinoma group treated with silymarin (HCC+S), while the fourth was the hepatic cell carcinoma group treated with taurine (HCC+T) and the fifth was the hepatic cell carcinoma group treated with both silymarin and taurine (HCC+S+T). Blood samples were collected after one, two and three months from five animals of each group for biochemical analysis; however liver was collected at the end of the experiment for histopathological examination. Our obtained data confirmed that silymarin in combination with taurine have a powerful chemotherapeutic effect against NDEA induced hepatic cell carcinoma in rats.