Status of TNF alpha polymorphism in different phases of Chronic Hepatitis B

Chronic hepatitis B is a severe form of liver infection. The host immune response plays an important role in the progression of the disease. This host pathogen interaction results into different phases of chronic hepatitis B. In this study we have tried to analyze the role of TNF-? polymorphism in the four phases of chronic hepatitis B to see if the polymorphism has got any role in the disease progression. We found that TNF-? 308 homozygous GG genotype was frequently associated with immune reactive state and progressed to chronic hepatitis in HBeAg positive subjects whereas heterozygous AG genotype was associated with non reactive subjects.