The significance of H-FABP and BNP levels in diagnosis of acute myocardial infarction.
- Department of Biochemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.
- Department of clinical pathology, Cardiovascular hospital, Ain Shams University, Abbassia, Cairo, Egypt.
- Poison control center, Ain Shams University, Abbassia, Cairo, Egypt.
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Early interventions aimed at restoring coronary blood flow in patients with acute myocardial infarction (AMI) reduces myocardial damage and improves patient outcome. Yet, a timely diagnosis can be a diagnostic challenge for the clinician. We aimed to compare the potential diagnostic efficacy of Brain-type natriuretic peptide (BNP) and heart-type fatty acid binding protein (H-FABP) with other cardiac-markers to examine their usefulness in early confirmatory markers of acute myocardial infarction. Eighty subjects were recruited in this study, including 40 AMI patients, 40 patients suffering from non-cardiac chest pain as well as 10 healthy subjects. Receiver Operator Characteristic Curve (ROC) analysis showed H-FABP to be a good discriminator between patients with AMI and patients without AMI. Both H-FABP and BNP were found to be more sensitive than troponin (89%, 79.5% vs.61.3%), in the same line, H-FABP and BNP showed higher specificity when compared to troponin (89.9%, 82.4%, vs. 61.5%) in diagnosing of AMI. In conclusion; H-FABP is a promising discriminator biomarker for the early detection of patients with acute myocardial infarction admitted within 3-6 hours from the onset of chest pain either alone or in combination with troponin.
[Mostafa M. Elhady, Marwa G. A. Hegazy, Heba M. Elsayegh and Wafik A. Elkhayat. (2016); The significance of H-FABP and BNP levels in diagnosis of acute myocardial infarction. Int. J. of Adv. Res. 4 (Feb). 1342-1348] (ISSN 2320-5407). www.journalijar.com
