COMPARATIVE STUDY OF LEVOSIMENDAN VERSUS DOBUTAMINE IN VIEW DIFFERENCE IN MEAN HEART RATE , SBP & DBP BETWEEN TWO GROUPS IN PATIENTS OPERATED FOR CARDIACSURGERY PATIENTS IN TERTIARY CARE HOSPITAL.

Introduction:- Cardiopulmonary bypass is associated with clinically asymptomatic to clinically symptomatic myocardial injury . Oxygen & ATP deprivation and/or reperfusion injury following cross clamp removal are associated with myocardial insult. Levosimendan has also been used in this context but only in a small number of patients so the clinical-experience is very limited. So we studied a comparison between levosemendan and dobutamine in on-pump surgery patients. Methods:- 60 patients posted for CABG in cardiac on pump surgeries. They were allocated randomly to two equal groups (Group L - inj. levosimendan 12?g/kg over 10 minutes after cross clamp removal and 0.1?g/kg/min started after that andinj.Dobutamine 5 ?g/kg/min infusion at the time of weaning from cardiopulmonary bypass) from feb 2014 to july 2015 at dheeraj general hospital piparia Vadodara.. Results:- In our study we found there was statistically significant difference in mean heart rate between two groups (p˂0.001).Heart rate increased more in the levosimendan group than in the dobutamine group. there is no statistically significant difference in systolic and diastolic blood pressure in both groups(p>0.05). Conclusion:-Levosemendan is better than dobutamine in maintaining hemodynamic stability during intraoperative and postoperative period of patients coronary artery bypass graft going for on-pump surgery