Vol. 4 (05) pp. 1119-1128 DOI: 10.21474/IJAR01/486

ANTIMICROBIAL ACTIVITY OF HYDROCHLOROTHIAZIDE SCHIFF BASE AND THEIR METAL ION COMPLEXES.

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  • Department of Chemistry, Columbia Institute of Engineering and Technology, Raipur (C.G.) India, 491001.
  • Vicon Pierson School, Raipur (C.G.) India 492001.
  • Deparment of ChemistyShri Jagdish Prasad JhabarmalTibrewalaUniversity ,Jhunjhunu, Rajisthan, 333001.
  • Department of Biotechnology, MooljiJaitha College, Jalgaon (M.H.), 425001.
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Abstract

The synthesis of four metal complexes of hydrochlorothiazide Schiff base is reported. The compounds were obtained by the condensation of hydrochlorothiazide and salicylaldehyde, followed by the synthesis of their Cd(II), Ni(II), Zn(II) and Co(II) metal complexes. Structural characterization was done using 1H and 13C NMR, MASS, IR, UV-Vis spectroscopy and elemental analysis. Prepared compounds were screened for their antimicrobial activity. Obtained results were compared with those of parent drug hydrochlorothiazide. The increased antimicrobial potency of all compounds were recorded; excellent activity was reported for Co(II) and Cd(II) complexes.

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How to Cite This Article

Hitendra Kumar Lautre, Snigdha Das, Pramod Mahour and Kishore Patil. (2016); ANTIMICROBIAL ACTIVITY OF HYDROCHLOROTHIAZIDE SCHIFF BASE AND THEIR METAL ION COMPLEXES., Int. J. of Adv. Res., 4 (05), 1119-1128, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/486

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HITENDRA KUMAR LAUTRE

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