Identification and synthesis of process related unspecified impurities of betahistine dihydrochloride.
- Inogent Laboratories Private Limited, Department of Research & Development, 28A, IDA, Nacharam, Hyderabad 500 076, India.
- Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500 072, India.
- IPCA Laboratories Ltd, Chemical Research and Development, Plot- 123AB, Charkop, kandivali industrial Area, Kandivali (West), Mumabi 400 067, India.
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Abstract
Herein, we describe the syntheses and characterization of process related impurities of anti-vertigo drug betahistine dihydrochloride. We have identified seven impurities during the synthesis of betahistine dihydrochloride from 2-pyridineethanol. Among that, four impurities such as N-acetyl betahistine, 2-(pyridine-2-yl)ethyl acetate, N-methyl betahistine and N-methyl-2-(pyridine-2-yl)prop-2-en-1-amine are not reported in the literature. In this article, we describe the origin, syntheses and characterization of three of these unspecified impurities.
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How to Cite This Article
Nagender Rao D, Reguri Buchi Reddy, Mukkanti K, Joseph Prabahar K, Thanasekaran Ponpandian, Venu Konda, Purandhar Koilkonda and Seshagiri Rao M (2016); Identification and synthesis of process related unspecified impurities of betahistine dihydrochloride., Int. J. of Adv. Res., 4 (03), 842-848, ISSN 2320-5407.
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