EFFECT OF PURIFIED METABOLITES OF PENICILLIUMMARNEFFEI AND GEOTRICHUMCANDIDUM AGAINST LARVAE OF CULEXQUINQUEFASCIATUS (DIPTERA:CULICIDAE).

Penicillium marneffei and Geotrichum candidum are known to be dimorphic and keratinophilic fungi and effective mosquito control agents. The current research evaluates the efficacy of the fungi P. marneffei and G. candidum as biological agents in the control of larval instars of the mosquito Cx. quinquefasciatus. Different concentrations of P. marneffei and G. candidum fungi metabolites purified by column chromatography had various effects on the mortality of the larvae of this mosquito. The larval mortality rates (first, second, third and fourth) instars were respectively LC50=0.71, LC50=0.587, LC50=0.684, LC50=0.746 at the concentration of 1.8 ml/cm 2, and after 72 hours of treatment by P. marneffei; while for G. candidum, the larval mortality rates (first, second, third and fourth) instars were respectively LC50=0.579, LC50=0.649, LC50=0.755, LC50=0.855 at the concentration of 1.8 ml/cm 2, and after 72 hours of treatment.